Related studies have also found that miRNAs regulate lipid metabolism in milk (Lian et al., 2016), liver cancer cells (Cui et al., 2014), laying hens (Tian et al., 2019), and pig subcutaneous fat (Shan et al., 2022) by targeting ACSL1. Based on these results, ACSL1 plays a key regulatory role in the synthesis of unsaturated fatty acids. The gene discussed is ACSL1; the disease is liver cancer.