We found that all of the 13 CRRs were DEGs between BC and normal samples, among which seven regulators (DLD, PDHB, ATP7B, DLAT, SLC31A1, ATP7A, DBT) were upregulated and six regulators (FDX1, LIPT1, LIAS, GCSH, DLST, PDHA1) were downregulated in BC samples (Figure 2A). The gene discussed is ATP7A; the disease is breast cancer.