We found negative correlation between FDX1 expression and genomic instability parameters such as tumor mutation burden (TMB), microsatellite instability (MSI), homologous recombination deficiency (HRD), loss of heterozygosity (LOH) and neo-antigen (NEO) etc. in CRCA, CESC, LIHC, LUAD, TGCT, THCA and THYM. This evidence concerns the gene FDX1 and neoplasm.