As shown in Figure 5A, FDX1 expression was negatively correlated with the expression of immune checkpoints such as CD274 (PD-L1), CTLA-4, TIGIT etc. In most tumors including ACC, BLCA, LAML, STAD and THCA etc.; while the expression of FDX1 was positively correlated with the expression of immune checkpoints in BRCA, KICH, LGG and PCPG etc. This evidence concerns the gene TIGIT and adrenal cortex carcinoma.