As shown in Figure 5A, FDX1 expression was negatively correlated with the expression of immune checkpoints such as CD274 (PD-L1), CTLA-4, TIGIT etc. In most tumors including ACC, BLCA, LAML, STAD and THCA etc.; while the expression of FDX1 was positively correlated with the expression of immune checkpoints in BRCA, KICH, LGG and PCPG etc. The gene discussed is CTLA4; the disease is adrenal cortex carcinoma.