TMEM106B and cancer: Li et al. (2017) reported that dysregulation of USP9X, an integral component of centrosome and a requisite for centrosome biogenesis, contributed to centrosome amplification, chromosome instability, and breast cancer. TMEM106B is a transmembrane protein located on cellular lysosomes. Kundu et al. (2018) demonstrated that TMEM106B-induced lysosomes released active lysosomal cathepsins necessary for cancer cell invasion and metastasis.