Based on the Disease Ontology (https://disease-ontology.org/) database, six genes in the final leader genes of colon cancer were confirmed to be involved in the occurrence of colon cancer, such as CCND1, whose overexpression significantly increased the progression of cancer (Li et al., 2021), and CDKN1A, which is a tumor suppressor of colon cancer (Halaburková et al., 2017). The gene discussed is CDKN1A; the disease is malignant colon neoplasm.