The TP53 missense mutation, giving rise to the Lysine (K) to Arginine (R) substitution at codon 120 (here indicated as p53K120R), is an example of a DNA contact alteration found in cancers able to maintain some DNA binding capacity in virtue of the positive charge preservation of the amino acid side chain, which allows a heterogenous transcriptional activity (Liu et al., 2019; Xia et al., 2022). Here, TP53 is linked to cancer.