Simultaneously, according to the traditional histopathological subtypes, PTEN inactivation is a major driver of endometrioid carcinomas; TP53 inactivation is a major driver of most serous carcinomas, some high-grade endometrioid carcinomas, and many uterine carcinosarcomas; and inactivation of either gene is a major driver of some clear cell carcinomas (Bell and Ellenson, 2019; Urick and Bell, 2019). The gene discussed is PTEN; the disease is clear cell adenocarcinoma.