VEGFA and neoplasm: Furthermore, hypoxia and vascularization are mutually strengthening (Malekan et al., 2021) Numerous studies have shown that upregulation of HIF-1α/VEGF signaling pathway will promote tumor cell migration, invasion and melanoma angiogenesis (Zheng et al., 2020; Roy et al., 2021; Xu et al., 2021).