For tumor pathological stage (Figure 6A), the results indicated that MMP3, DEAF1, IFNGR1, HIF1A, PIN1, HNRNPU, TICAM2 and HMOX1 groups varied significantly (p < 0.05), and MMP3 was highly correlated with stage II skin melanoma (F value = 7.77, p = 4.85E-06). This evidence concerns the gene HNRNPU and cutaneous melanoma.