In summary, based on our systematic analyses of m7G regulators, we demonstrated the correlation between the differential expression of m7G regulators and patient survival, cancer immune landscape and tumor microenvironment, and concluded that the altered expression of WDR4, METTTL1, NUDT1, IFIT5, and CYFIP2 were associated with poor prognosis in cancer patients. The gene discussed is WDR4; the disease is neoplasm.