While subcutaneous injection of insulin or oral/nasal administration of sugar-lowering drugs have been proved as the crucial drug delivery systems over the last years, recent pharmacotherapeutic approaches, exploiting i.e., nanotechnologies, provide nowadays important alternatives into resolving some of the most several limitations of conventional anti-diabetes medications (Veiseh et al., 2015; Todaro et al., 2022). Here, INS is linked to diabetes mellitus.