Here, we analyzed genes encoding key components of the Myddosome complex, including IRAK1, IRAK4, and MYD88, and the TLR adaptor protein TRAF6, using recently published single-cell RNA-seq data of PCa (17), The Cancer Genome Atlas (TCGA) data bank, and in vitro cell culture experiments, with a focus on their epigenetic regulation in PCa. The gene discussed is IRAK4; the disease is posterior cortical atrophy.