Two CpG sites flanking this DMR were significantly hypomethylated in PCa (cg23604959 and cg02742918), and their methylation status showed an inverse correlation with IRAK1 mRNA levels in PCa (n=341, Spearman coefficient =-0.36 and -0.37, respectively) (Figure 3B). The gene discussed is IRAK1; the disease is posterior cortical atrophy.