In contrast, weak DNA methylation in IRAK1-DMR, as was found in the PCa cell lines PC3 and LNCaP, was accompanied by a 2-3-fold higher endogenous IRAK1-mRNA expression than in DU145 cells, and with only a moderate activation of IRAK1 expression upon 5-AZA and TSA treatment (maximum 169%). Here, IRAK1 is linked to posterior cortical atrophy.