Knockdown of METTL14 and YTHDF1 could reduce mRNA transcript levels of interferon signaling IFNA/IFNB/IFNG/ISG5, which is involved in the formation of the gastric cancer (GC) microenvironment and suppresses the antitumor immunity mediated by interferon signaling blocking (68, 69). This evidence concerns the gene IFNB1 and gastric cancer.