As a carcinogenic gene, upregulation of METTL3 promotes the occurrence and development of RB through the PI3K/AKT/mTOR signaling pathway (20). METTL14, another “writer” protein, usually works in combination with METTL3 as a dimeric form, which is required to stabilize the METTL3 conformation and facilitate RNA-binding. This evidence concerns the gene METTL3 and retinoblastoma.