NPM1 and acute myeloid leukemia: indicated that FTO is abnormally upregulated in AML subtypes with t (11q23)/MLL-rearranged (Mixed Lineage Leukemia gene), t (15, 50), FLT3–ITD (fms-related receptor tyrosine kinase 3) and/or NPM1-mutated (nucleophosmin 1).