The present study also performed univariate analysis to evaluate the predictive value of clinicopathologic factors for PFS and OS, including sex (male vs. female), age (<65 vs. ≥65), treatment program (RS vs. FS), primary tumor site (left colon vs. right colon), liver metastasis (with vs. without), KRAS status (wide type vs. mutant), MPV (<9.9 vs. ≥9.9), NLR (<2.15 vs. ≥2.15), LDH (<312 vs. ≥312) and D-Dimer (<0.89 vs. ≥0.89). This evidence concerns the gene KRAS and metastasis.