Grade 3-4 AEs were decreased platelet (n=1, 1.4%), increased ALT/AST (n=2, 2.8%), secondary hypertension (n=4, 5.6%), hand-foot syndrome (n=2, 2.8%), rash (n=1, 1.4%) and pneumonitis (n=1, 1.4%). This evidence concerns the gene GPT and Hand-foot syndrome.