IL-6 can induce the formation of signals, transduction protein and transcriptional activation factor-3 and makes joint efforts in TGF-β1 generation and epithelial conversion, inhibiting T-cell proliferation and killing effect and activating Treg, which plays the key role in the immunization of colorectal cancer and is related to the adverse prognosis (24). The gene discussed is IL6; the disease is colorectal cancer.