IL-6 can induce the formation of signals, transduction protein and transcriptional activation factor-3 and makes joint efforts in TGF-β1 generation and epithelial conversion, inhibiting T-cell proliferation and killing effect and activating Treg, which plays the key role in the immunization of colorectal cancer and is related to the adverse prognosis (24). This evidence concerns the gene ATF3 and colorectal cancer.