YTHDF2 and neoplasm: Accordingly, elevated levels of global and specific H3K18 histone lactylation in ocular melanoma tissues have been associated with poor patient prognosis, which could be related to the transcriptional levels of the novel oncogene YTH N6 methyladenosine RNA binding protein (YTHDF2) in tumor-initiating myeloid cells (Figure 1) (29).