HIF-1 is an important transcription factor in the adaptation of tumor cells to hypoxia, and directly or indirectly regulates cell proliferation and angiogenesis during the progression of tumor hypoxia microenvironment gene expression related to apoptosis and energy metabolism, whose transcriptional activity is a significant positive regulator of tumor progression and metastasis potential (25, 26). Here, HIF1A is linked to neoplasm.