In another report, copper, which in excess is a potent oxidant causing the production of ROS in cells (171, 172), through the EGFR/ERK/c-Fos pathway, increased the expression of VEGF, HIF-1α, and G-protein estrogen receptor (GPER) in the SKBR3 BC cells (173, 174). The gene discussed is EGFR; the disease is breast cancer.