Divided into three parts, the experiment evaluated the efficacy of dual wavelength laser in the treatment of chronic periodontitis by observing the clinical indexes (PD, BOP, Cal), the content of Pg in subgingival plaque relative to total bacteria and the changes of TNF-α, IL-1β, b-FGF, and TGF-β in gingival crevicular fluid so as to provide a new treatment mode for clinical laser treatment of periodontitis [3]. The gene discussed is FGF2; the disease is periodontitis.