After removing the synonymous variants, the heterozygous variant c.2530G > T (p.Ala844Ser) in WFS1 was identified as the only candidate variant consistent with the autosomal dominant inheritance patterns in this Chinese family, i.e., the heterozygous state of WFS1 variant can cause HL in affected family members. The gene discussed is WFS1; the disease is Hodgkins lymphoma.