Since sST2 is less influenced by age and renal insufficiency than N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT) (14, 15), it has been entered into guidelines in heart failure and considered to provide additive prognostic value and as a guide to therapy decision-making of heart failure (16). Here, NPPB is linked to heart failure.