Then, Sabatine et al. measured ST2 at baseline in 1,239 patients with STEMI from the CLARITY-TIMI 28 trial, which showed that a high baseline ST2 level, irrespective of baseline features and NT-proBNP, is a strong predictor of cardiovascular mortality and heart failure in STEMI, and the combination of ST2 and NT-proBNP greatly enhances risk stratification (36). This evidence concerns the gene IL1RL1 and heart failure.