AKT1 and neoplasm: The findings of the pathway-based ssGSEA demonstrated that the C1 subtype activates a greater number of tumor-related pathways, such as PI3K_AKT_MTOR_SIGNALING, INTERFERON_ RESPONSE, P53_PATHWAY, INFLAMMATORY_RESPONSE, KRAS_SIGNALING, APOPTOSIS, HYPOXIA, TGF_BETA_SIGNALING, and EPITHELIAL_MESENCHYMAL_TRANSITION, suggesting the close association of ICD with above typical tumor-associated pathways (Figure 3F).