Binding of TIGIT to CD155 ligand overexpressed on tumor cells led to immune escape while also suppressing innate and adaptive immunity, including inhibition of NK-mediated cytotoxicity and IFN-γ production, inhibition of DCs produces IL-12, inhibition of CD4+ T, CD8+ T cells proliferation, and induction of IL-10 production (92). This evidence concerns the gene CD4 and neoplasm.