In addition, the metastasis of GC can be promoted through the inhibition of serine/threonine protein kinase 24 (STK24) expressed in normal and GC tissues, and this promotion was achieved by inducing overexpression of the GC stem cell marker CD44, enhancing CD11b+Ly6C+ MDSCs in the mouse spleen, and inducing their expansion (276). The gene discussed is ITGAM; the disease is gastric cancer.