In addition, the expression of long non-coding RNA (lncRNA) target genes NOX4, COL8A1, and CHST1 was positively correlated with the degree of infiltration of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs in the immune microenvironment, and these lncRNA target genes may be involved in the formation of the tumor immune microenvironment (333). This evidence concerns the gene CD4 and neoplasm.