Furthermore, the CXCL/CXCR1/2 signaling axis is critical for neutrophil recruitment (300) and inhibition of CXCR1/2 signaling can reduce neutrophil recruitment (301); in addition, CXCR2 blockade as a single drug can prevent TAN accumulation and reduce tumor burden in tumor-bearing mice and can also enhance the efficacy of chemotherapy and immunotherapy (302, 303). This evidence concerns the gene CXCR1 and neoplasm.