However, studies have shown that neoadjuvant chemoradiotherapy (gemcitabine + S-1 followed by radiation therapy (30 Gy)) induces the overexpression of MHC class I-related chain A/B (90), a membrane protein expressed in cancer cells that is induced by irradiation or chemotherapy, and interacts with natural killer group 2 member D to enhance the killing effect of NK cells on cancer cells (89, 104, 105). Here, MICA is linked to cancer.