Neoadjuvant chemoradiotherapy (gemcitabine + S-1 followed by radiation therapy (30 Gy)) has been reported to induce the overexpression of DAMPs (such as MICA/B, calreticulin, and Hsp70), increase the number of CD8+ and CD4+ tumor-infiltrating T lymphocytes, and decrease the ratio of Treg/tumor-infiltrating T lymphocytes (90). Here, CD4 is linked to neoplasm.