Because the FDX1 gene encodes a reductase that reduces Cu2+ to a more toxic Cu1+, given the pivotal role of the FDX1 gene in cuproptosis, we hypothesized that the FDX1 gene might help to evaluate the occurrence of this copper-induced cell death in ccRCC. This evidence concerns the gene FDX1 and nonpapillary renal cell carcinoma.