To check if somatic mutations are linked to the NET-scores, we conducted the Genomic Identification of Important Targets in Cancer (GISTIC) analysis and the results showed that HNSCC patients with either high or low NET-scores manifested respective somatic mutations, including TP53, PIK3CA, NOTCH1, and MUC17 (Figures 4A, B). The gene discussed is NOTCH1; the disease is head and neck squamous cell carcinoma.