The levels of the proteases in four patients subsequently deceased from COVID-19 were comparable to the levels in the patients with severe COVID-19: CPA3 (21.54 ±6.6 vs. 22.25 ±5.7 ng/ml, p = 0.72); CMA1 (2426 ±1113 vs. 2387 ±720 ng/ml, p = 0.73) and for TPSB2 (27.5 ±17 vs. 30.04 ±17 ng/ml, p=0.95). This evidence concerns the gene TPSB2 and COVID-19.