In addition, inactivation of Mettle3 in NK cells changed the hemostasis, infiltration and function of NK cells in the tumor microenvironment, leading to accelerated tumor growth and short lifespan in mice by modifying SHP-2 mRNA, which rendered NK cells hyporesponsive to IL-15 (94) (Figure 5B). The gene discussed is PTPN11; the disease is neoplasm.