METTL3, WTAP, IGF2BP3, YTHDF1, HNRNPA2B1 and HNRNPC were markedly increased in esophageal squamous cell carcinoma (ESCC) and positively related to the expression of PD-1, whose copy number dynamically affects the enrichment of tumor-infiltrating immune cells (128). This evidence concerns the gene YTHDF1 and esophageal squamous cell carcinoma.