In addition, the RNA demethylase FTO and HLA-G were significantly decreased in the trophoblasts of spontaneous abortion (SA) patients, and the mRNA expression of VEGFA, VEGFR and MMP2 bound to YTHDF2 also decreased in SA patients, which indicated that FTO in the chorionic villi promotes immune tolerance and angiogenesis at the maternal-fetal interface due to aberrant methylation and oxidative stress and therefore leads to the occurrence of SA (67). The gene discussed is FTO; the disease is abortion.