AMPK phosphorylation can inhibit the cleavage and maturation of SREBP-1, subsequently attenuating hepatic steatosis through regulating lipogenic genes (74), so it is possible that the dietary carotenoids in the orange carrot could reduce SRBEP-1 cleavage through promoting the phosphorylation of AMPK. This evidence concerns the gene SREBF1 and Hepatic steatosis.