For reasons similar to those put forward for creatinine and cystatin C, a larger difference between cystatin C- and creatinine-eGFR has been associated with lower frailty, injurious falls, hospitalization, CVEs, and mortality in adults with hypertension of a cohort of the Systolic Blood Pressure Intervention Trial (SPLINT) (24). The gene discussed is CST3; the disease is hypertensive disorder.