In this context, in the last few years, increased obesity prevalence as a consequence of a sedentary lifestyle and low physical activity has been linked to systemic, chronic low-grade inflammation processes through adipocyte-secreted hormones (adiponectin, leptin, resistin, and ghrelin), growth factors and proinflammatory cytokines (83). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.