VIP and Huntington disease: Here, we have performed a thorough morphological analysis of three major populations of cortical interneurons – PV, SST, and VIP cells – in two widely used mouse models of HD, the R6/2 transgenic fragment model (Mangiarini et al., 1996) and the zQ175DN full-length knock-in model (Menalled et al., 2012; Southwell et al., 2016).