Ectopic expression of the calcium voltage-sensitive channel Cav1.3 in HEK-293 cells proved sufficient to enable glucose-dependent depolarization, triggering intracellular calcium signaling. This was rerouted to NFAT-operated minimal promoters for the expression of GLP-1 or mouse insulin to treat the hyperglycemia-inducing condition. The gene discussed is INS; the disease is Hyperglycemia.