Nine of the 11 genes (AKR1B1, BAG3, CDK18, ETS2, G6PD, GRK6, ITPK1, KDM5B, MAP4K1, SMURF2, and SOCS1) were upregulated, while the other two genes were downregulated in AML (Figure 1C). The gene discussed is AKR1B1; the disease is acute myeloid leukemia.