SMURF2 and acute myeloid leukemia: Nine of the 11 genes (AKR1B1, BAG3, CDK18, ETS2, G6PD, GRK6, ITPK1, KDM5B, MAP4K1, SMURF2, and SOCS1) were upregulated, while the other two genes were downregulated in AML (Figure 1C).