TLR4 and Alzheimer disease: Regarding the results found in the cortical white matter, control and WE cases showed faint TLR4 staining (Figures 3A,B), but a higher TLR4 immunoreactivity was detected in the AD patient mostly between the fibers and in glial cells, showing that the AD case has a higher TLR4 expression than the WE case (p = 0.0028) (Figure 3C; F (2, 20) = 7.53, p = 0.0036).