NFKB1 and thanatophoric dysplasia: Indeed, this autoregulatory mechanism switched on by NF-κB to block its stimulation is widely known in neuroinflammatory studies induced by LPS (Sayd et al., 2015), alcohol (Doremus-Fitzwater et al., 2015; Gano et al., 2016), TD (Moya et al., 2021), or combined TD and alcohol (Toledo Nunes et al., 2019).