STAT3 also plays a role in macrophage-mediated post-MI repair, mainly through the IL10-STAT3-Galectin 3 axis promoting osteopontin-mediated generation of reparative macrophages, which promote MI by stimulating fibrosis and the clearance of apoptotic cells (Shirakawa et al., 2018). The gene discussed is STAT3; the disease is myocardial infarction.