REN and hydrops fetalis: Based on previous work on the HF mechanism, our results suggest that FZYX may act in HF through the advanced glycation end-product (AGE)-receptor for AGE (RAGE) signalling pathway, arachidonic acid metabolism, the high-affinity receptors for immunoglobulin E (Fc epsilon RI) signalling pathway, the prolactin signalling pathway, nicotinate and nicotinamide metabolism, the forkhead box O (FOXO) signalling pathway, apoptosis, the adipocytokine signalling pathway, the renin-angiotensin system, and the cyclic guanosine monophosphate (cGMP)- protein kinase G (PKG) signalling pathway.