Such a decrease in ApoA-I or HDL-C is a common finding in cytokine storms and was observed in virus-induced and familial hemophagocytic lymphohistiocytosis (HLH) (Henter et al., 1991; Kraskovsky et al., 2021) and in dengue shock syndrome (Marin-Palma et al., 2019). The gene discussed is APOA1; the disease is hereditary hemophagocytic lymphohistiocytosis.