Recent studies have established that NF-κB expression is upregulated in a high glucose environment, and that inhibiting the NF-κB signaling pathway can effectively reduce cardiac oxidative stress and myocardial fibrosis, and reverse the deterioration of cardiac function (Liu et al., 2020; Youssef et al., 2021). Here, NFKB1 is linked to Myocardial fibrosis.