NOX1 and hypertensive disorder: NOX1 has been reported to be associated with a variety of cardiovascular diseases, mainly atherosclerosis, hypertension, and ischemia/reperfusion injury (Szocs et al., 2002; Dikalova et al., 2005; Niu et al., 2010; Braunersreuther et al., 2013; Sobey et al., 2015).