Inhibited functions included gangrene-induced cell death (HIST1H1C, C9, ACP1, PPIA, etc.), leukocyte recruitment and inflammatory response (APOA1, MBL2, LTF, APOH, LBP, C5, etc.), nerve cells (MIF, P4HB, TF, C9, etc.), tissue cell death (RPL27A, RPS19, ENO1, MIF, etc.), and bacterial growth (APOA1, LTF, TF, GSN, etc.). This evidence concerns the gene APOA1 and gangrene.