Inhibited functions included gangrene-induced cell death (HIST1H1C, C9, ACP1, PPIA, etc.), leukocyte recruitment and inflammatory response (APOA1, MBL2, LTF, APOH, LBP, C5, etc.), nerve cells (MIF, P4HB, TF, C9, etc.), tissue cell death (RPL27A, RPS19, ENO1, MIF, etc.), and bacterial growth (APOA1, LTF, TF, GSN, etc.). Here, P4HB is linked to gangrene.