CREB1 and histiocytoma, Angiomatoid fibrous: At molecular level, AFH is associated with three characteristic translocations: t(2:22)(q33:q12) (forming the EWSR1-CREB1 fusion gene) [17,18], t(12:22)-(q13:q12) (forming the EWSR1-ATF1 fusion gene) [18-20], and t(12:16)(q13:p11) (resulting in the FUS-ATF1 fusion gene) [21,22].