Compared with the CRC group, the Lactobacillus fermentum-treated group had lower detection levels of inflammatory signaling pathway stimulators IL-1β and TNF-α, and increased expression of the activating protein IKKβ, resulting in the degradation of IκBα and the increase in the expression of aggregate NF-κB. Here, NFKB1 is linked to colorectal carcinoma.