Specific histological subtypes within cancers may also be suggestive of an underlying cancer predisposition, such as increased likelihood of germline TP53 mutations among those with hypodiploid acute lymphoblastic leukemia (ALL) (51), germline APC mutations among those with WNT subtype medulloblastoma (28, 52), and germline BRCA mutations among those with triple negative breast cancer (53). Here, APC is linked to cancer.