Assuming that the overall population frequency of germline cancer mutations in pediatrics is similar to adult data, which indicate that the most common mutations are within Lynch syndrome genes and BRCA1/2, affecting 1 in 279 and 1 in 400 Americans, respectively (61, 62), underrepresents the demographic as all who developed cancer and did not survive adulthood are removed from the denominator. Here, BRCA1 is linked to cancer.