In addition, they were enriched in PI3K/AKT signaling cascade, relaxin signaling cascade, axon guidance, and focal adhesion cascade, proteoglycans in the cascades associated with various carcinomas, AGE-RAGE signaling cascade in diabetic complications, RA cascade, Protein digestion, and absorption cascade, ECM-receptor interaction and TNF signal transduction cascades (Figure 7B). Here, TNF is linked to rheumatoid arthritis.