ASXL1 and Bohring-Opitz syndrome: Tumors susceptibility has been studied also for BOPS and was found that, although isolated reports on BOPS children seem to suggest a greater risk for Wilms tumor, sporadic malignancies in absence of other BOPS findings more frequently harbor somatic ASXL1 pathogenetic variants (Russell et al., 2018) which increase the risk of myelodysplastic syndrome as shown in mice (Abdel-Wahab et al., 2013; Wang et al., 2014).