Therefore, loss of function of Cbp and p300 leads to these similar defects in mouse models (Tanaka et al., 1997; Yao et al., 1998; Oike et al., 1999; Viosca et al., 2010) together with multilineage defects in hematopoiesis (Kung et al., 2000; Kasper et al., 2002), which in Cbp ± mice can increase the incidence of hematologic malignancies, as observed in RSTS patients (Kung et al., 2000; Boot et al., 2018). Here, CREBBP is linked to Rubinstein-Taybi syndrome.