RNA Methyltransferase, METTL3-mediated RNA stabilization positively regulates major signalling pathways such as Notch, NFκB, Wnt, c-Myc, TGFβ, involved in cancer stem cell maintenance and proliferation in several cancers including Glioma and Leukemia maintenance and tumorigenesis implying its oncogenic role (Visvanathan et al., 2018). The gene discussed is TGFB1; the disease is cancer.