NFE2L2 and alcoholic liver diseases: Nrf2 can inhibit ferroptosis in alcoholic liver disease by regulating SLC7A11 and HO-1, and specific knockout of the Nrf2 gene can reduce the expression of SLC7A11 and inhibit the activity of GPX, thus enhancing the sensitivity of PC12 cells to ferroptosis induced by erastin (Qiang et al., 2020; Dong et al., 2021a).