Decreased expression of the lncRNA MIAT promoted the occurrence of ferroptosis by downregulating the expression of Nrf2 and Nrf2 in the nucleus, reducing cell viability, damaging renal tubular epithelial cells and exacerbating the progression of DKD (Yan et al., 2015; Zhou et al., 2015; Ji et al., 2020; Xiao et al., 2021; Wang Z. et al., 2022). This evidence concerns the gene NFE2L2 and diabetic kidney disease.