LncRNA MALAT1 was significantly upregulated in mice with diabetic cardiomyopathy and in cardiomyocytes induced by high glucose, and knocking down lncRNA MALAT1 expression could significantly improve apoptosis induced by high glucose and inhibit mir-181A-5p expression (Michalik et al., 2014; Leung and Natarajan, 2018; Zhang et al., 2019b; Li et al., 2021a; Tanwar et al., 2021). This evidence concerns the gene MALAT1 and diabetic cardiomyopathy.