Notably, PGC-1α deficiency in adults leads to abnormal myelination, neurodegeneration, and structural abnormalities seen in amyotrophic lateral sclerosis (ALS), Parkinson’s, Huntington’s, and Alzheimer’s diseases in adult humans and animal models (Lin et al., 2004; Leone et al., 2005; Zheng et al., 2010; Thau et al., 2012; Tsunemi et al., 2012; Johri et al., 2013; Lucas et al., 2015; Sweeney and Song, 2016; Mota and Sastre, 2021; Piccinin et al., 2021). This evidence concerns the gene PPARGC1A and amyotrophic lateral sclerosis.