GHRL and overnutrition: In animal models, only neonatal overnutrition obtained by manipulating litter size has been studied so far: it reduced plasma acylated and total ghrelin levels (Collden et al., 2015), increased acylated ghrelin gastric tissue content (Du et al., 2015) as well as goat mRNA levels (Collden et al., 2015) while at the central level, it reduced hypothalamic ghsr mRNA level and ghrelin sensitivity during the neonatal period in mouse models (Collden et al., 2015).