However, whether phosphate release occurs before or after the stroke is still a matter of debate (Houdusse and Sweeney, 2016; Planelles-Herrero et al., 2017) In the presence of OM, the phosphate release rate is increased; however the overall ATP turnover rate was slowed, owing to even greater slowing of the actin-induced rotation of the myosin light chain binding domain (Rohde et al., 2017). This evidence concerns the gene MYH14 and ocular melanoma.