MYH14 and familial dilated cardiomyopathy: Interestingly, one of the HCM mutations, P710R, shared properties with the DCM-causing mutations (Ujfalusi et al., 2018), including reduced ATPase activity (kcat), lower occupancy of the force holding actin-myosin-ADP state, a lower duty ratio and a more economical use of ATP for both rapid movement and force generation (Ujfalusi et al., 2018).