As discussed later, myosin and MyBP-C comprise the vast majority of mutations responsible for HCM (Maron et al., 2012; Semsarian et al., 2015), while titin is now recognized as the gene most frequently mutated in patients with idiopathic DCM, but is rarely associated with HCM (Herman et al., 2012; LeWinter and Granzier, 2013; McNally et al., 2013). Here, MYH14 is linked to familial dilated cardiomyopathy.