That at 6 weeks, limited blood tests will be performed (full blood count and differential, C‐reactive protein [CRP] or erythrocyte sedimentation rate [ESR]) coupled with increasing the dose of second generation antihistamines up to fourfold standard dose accompanied by monitoring disease activity and control with easy to use tools such as the urticaria activity score (UAS)55 or urticaria control test (UCT).49 This evidence concerns the gene CRP and urticaria.