Some plant substances and compounds are effective on wild-type and mutant p53 by inducing apoptosis or preventing cell proliferation, for example, Gemini curcumin and dendrosomal nano-curcumin in colorectal and breast cancer cell lines (Sobhkhizi et al., 2020; Ebrahimi et al., 2021). The gene discussed is TP53; the disease is breast carcinoma.