Prospective studies with randomization and standardized collection of pulmonary function tests, maxillofacial CT scans, serum IgE and complete blood counts with differential, and collection of SNOT-22, ACQ-5, ACT, and NOSE scores at regular intervals would provide useful increased data on the effect of biologic treatment in patients with asthma, allergic rhinitis, and chronic rhinosinusitis with sinonasal polyposis. The gene discussed is IGHE; the disease is allergic rhinitis.